GALACTICOIN: A new revenue stream for Real Madrid based on blockchain technology

White paper.SUMMARY: Football is indeed a beautiful game, and its appeal is unrivaled. This industry continues its pace as one of the fastest markets in the world and during the last years, the way clubs interact and engage with the fans has changed significantly due to digital transformation (KPMG, 2018a, pp.3), and the behavior of the new millennial generation. Likewise, fans and football supporters are looking to connect with their clubs and players, that’s why the participation on social media networks has increased, as well as the use of different technologies to enhance a better and personalized customer experience. Considering Real Madrid, as one of the leaders in the industry and the most valuable in terms of digital, how the club will face the fast development of technology to create a closer bonding with the upcoming generations? The current report is structured within five parts to provide an exciting project proposal that might boost the club’s potential, finding a solution to reach this challenging target market. The first part focuses on the situation analysis of the football industry and key industry trends plus an overall overview about Real Madrid (revenue, brand value, fans, digital strategy) introducing a current challenge the club is facing: Santiago Bernabéu renovation. Based on Real Madrid’s stadium case, the second part states the objectives and strategic planning to find a solution for the club through a new revenue stream based on a disruptive technology: the blockchain. For instance, the third part explains this technology and its advantages through a real example. Then, the report introduces the concept that the current project proposes: the Galácticoin for Real Madrid. The idea will be explained in detail, with all its benefits, timeline and the expected revenues. Finally, the document presents the conclusions based on a finance, brand value and fans perspective, according to the project objectives; the team chart description, advisors and references consulted

Sports industry research North America: USA & Canada

The Sports Industry is a potential business that not only involves the game at the field. It includes different aspects like food & beverage, apparel, sponsorship, licensing, events, tourism, and infrastructure (ATKearney, 2011). In North America this industry is one of the most important in terms of creating a positive impact to the economy, increasing surprisingly fast the GDP of the United States and Canada. The United States and Canada are the world’s biggest sports nations that provide a wide range of sport facilities and infrastructure and hosts yearly enigmatic events in key cities like Boston, New York, Los Angeles, Vancouver and Toronto. For this reason, we identified that these countries are a strategic move for any sports-related company to keep growing within the Sports Industry. The current report aims to provide a comprehensive research about the Sports Industry in North America, describing and analyzing possible investment opportunities in these countries for the upcoming years. The document is structured to explain an I) Overview of The Sports Industry in the United States and Canada, including the main sports leagues, secondary sports, sport facilities and new technology and trends. Then, we will discuss about the II) Main Leagues in North America considering its main teams, athletes, events, and highlight sport cases. Finally, we will describe the III) Sports Media Industry in North America, explaining about the Print, TV, Radio, Online channels and current media trends

“Rafiki Kahawa Shamba”: Developing “coffee tourism” in organic coffee farm to support local economic development in Tanzania

Final paper submitted to: AD650 Economic Development via Tourism in Developing World: Tanzania, Spring, 2017, Professor Samuel Mendlinger. Assignment #3: New Tourism Service for Tanzania

Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ

Hypertension affects nearly 20% of the population in Western countries and strongly increases the risk for cardiovascular diseases. In the pathogenesis of hypertension, the vasoactive peptide of the renin-angiotensin system, angiotensin II and its G protein–coupled receptors (GPCRs), play a crucial role by eliciting reactive oxygen species (ROS) and mediating vessel contractility. Here we show that mice lacking the GPCR-activated phosphoinositide 3-kinase (PI3K)γ are protected from hypertension that is induced by administration of angiotensin II in vivo. PI3Kγ was found to play a role in angiotensin II–evoked smooth muscle contraction in two crucial, distinct signaling pathways. In response to angiotensin II, PI3Kγ was required for the activation of Rac and the subsequent triggering of ROS production. Conversely, PI3Kγ was necessary to activate protein kinase B/Akt, which, in turn, enhanced L-type Ca2+ channel–mediated extracellular Ca2+ entry. These data indicate that PI3Kγ is a key transducer of the intracellular signals that are evoked by angiotensin II and suggest that blocking PI3Kγ function might be exploited to improve therapeutic intervention on hypertension

Sustainable Tourism for the Socio-economic Development of the Community of Vilca, Province of Yauyos, Department of Lima, Peru

The thesis Sustainable Tourism for the Socio-economic Development of the Community of Vilca, Province of Yauyos, Department of Lima, Peru, highlights the importance of negative and positive impacts of an effective and efficient management of sustainable tourism in an Andean Peruvian community. The study identifies strategies and mechanisms of how the commitment and self-organization of a community can make a contribution to the social and economic aspects through touristic activities. The project proposes the creation of a sustainable tourism company, Green Line S.A.C., which aims to work with the community of Vilca under the creation of a partnership agreement. The role of the company would maintain a relationship of strategic partnership, in charge of the economic, financial and operational management to the Nor Yauyos Cochas region. The member of this community would be responsible for carrying out the logistical and operational touristic programs in the community of Vilca. [TRUNCATED

Brain volume loss and no evidence of disease activity over 3 years in multiple sclerosis patients under interferon beta 1a subcutaneous treatment

The objective of our study was to evaluate the relationship of percentage of annualized brain volume loss (aBVL) and no evidence of disease activity (NEDA) in multiple sclerosis (MS) patients under interferon beta 1-a subcutaneous treatment (IFN-beta) during 3 years of follow up. Relapsing remitting MS (RRMS) patients, with less than three years from disease onset, expanded disability status scale (EDSS) ≤3 and in which IFN beta 1-a 44 mcg was indicated, were included. Demographic, clinical and structural parameters from the magnetic resonance (MR) during the 3 years of follow up were analyzed and compared between patients with and without NEDA (defined as the absence of: (a) three-month confirmed disability progression defined as an increase in EDSS score of 1.0; (b) confirmed relapses; and (c) new or enlarged T2 lesions and/or Gd+ lesions). A total of 87 patients, mean age 33 ± 6 years were included. NEDA was reached by 39 patients at year 3. Percentage of aBVL from baseline to months 24 in NEDA patients was −1.1% vs. −1.54% in patients without NEDA (p < 0.001) and from baseline to month 36 it was −1.43% vs. −2.1% (p < 0.001) in patients with and without NEDA, respectively. At 3 years follow up, patients who received IFN beta 1a and were disease-free had lower percentage of aBVL compared to patients with disease activity.Fil: Rojas, J.I.. Hospital Italiano; ArgentinaFil: Sánchez, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Caro, Fiorella Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Miguez, J. Hospital Italiano; ArgentinaFil: Patrucco, L.. Hospital Italiano; ArgentinaFil: Funes, J.. Hospital Italiano; ArgentinaFil: Cristiano, E.. Hospital Italiano; Argentin

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ

Adrenergic stimulation of the heart engages cAMP and phosphoinositide second messenger signaling cascades. Cardiac phosphoinositide 3-kinase p110? participates in these processes by sustaining ?-adrenergic receptor internalization through its catalytic function and by controlling phosphodiesterase 3B (PDE3B) activity via an unknown kinase-independent mechanism. We have discovered that p110? anchors protein kinase A (PKA) through a site in its N-terminal region. Anchored PKA activates PDE3B to enhance cAMP degradation and phosphorylates p110? to inhibit PIP(3) production. This provides local feedback control of PIP(3) and cAMP signaling events. In congestive heart failure, p110? is upregulated and escapes PKA-mediated inhibition, contributing to a reduction in ?-adrenergic receptor density. Pharmacological inhibition of p110? normalizes ?-adrenergic receptor density and improves contractility in failing hearts